Silver-Releasing Micro-/Nanoporous Coating on Additively Manufactured Macroporous Ti-Ta-Nb-Zr Scaffolds with High Osseointegration and Antibacterial Properties

The two major problems of titanium alloy surface bone/dental implants were the lack native tissue integration and associated infection. To solve these problems, development self-defending with intrinsic osteogenic properties has been highlighted, in which surfaces are endowed antibacterial property by silver (Ag) incorporated biomaterials. In this study, we biofunctionalized selective laser melting (SLM) manufactured volume-porous Ti-Ta-Nb-Zr scaffolds using plasma electrolytic oxidation (PEO) as a way to eliminate peri-operative bacterial load promote osseointegration. experiment, PEO process operated three different concentration (1, 1, 2 g/L) AgNO3 solution. As result, oxide coating embedded calcium phosphorous Ag was formed one-step treatment, presence HAp detected X-ray diffraction (XRD) XPS. addition, ions found be released from for at least 28 days, resulting an effective prevention adhesion decrease number planktonic bacteria, no sign cytotoxicity shown simultaneously. Highly porosity micropores on after oxidation, mechanical did not show any signs change. Besides, strong deposition osteoconductive effect PEO-treated scaffolds. sum up, study reveals potential coatings biofunctionalize SLM agents. biomaterials developed here, therefore, exploit behavior offer promotion without against mammalian cells.